Author: Abdullaeva Mохima Abdullaevna
Academic Degree: Doctor of Medical Sciences (DSc)
Specialties:
14.00.34 — Cardiovascular Surgery
14.00.33 — Public Health. Healthcare Management
Ischemic heart disease is one of the major causes of cardiovascular disease-related mortality among women. The clinical course of this disease in women has specific characteristics associated with reproductive and hormonal status, age-related changes, and the influence of comorbid conditions.
In the diagnosis and treatment of ischemic heart disease, it is important to consider women's individual clinical condition, the extent of coronary artery involvement, metabolic syndrome, diabetes mellitus, and other risk factors. The selection of an optimal myocardial revascularization method, assessment of surgical risk, and improvement of treatment outcomes determine the relevance of this research.
To improve the outcomes of myocardial revascularization in women with ischemic heart disease through a comprehensive diagnostic approach and factor analysis of clinical outcomes, with a focus on selecting the appropriate surgical treatment method.
To study the dynamics of cardiovascular disease incidence among women in the Republic of Uzbekistan and its regions.
To assess the clinical characteristics of ischemic heart disease in women according to reproductive status.
To analyze the influence of metabolic syndrome, including diabetes mellitus, obesity, dyslipidemia, and arterial hypertension, on disease progression.
To evaluate respiratory function parameters and the oxygen delivery index.
To conduct a comparative analysis of myocardial revascularization outcomes using endovascular interventions and coronary artery bypass grafting.
To develop individualized algorithms for selecting the appropriate revascularization method.
The study was based on the clinical data of 668 women with ischemic heart disease who received treatment at the Republican Specialized Scientific and Practical Medical Center of Surgery named after Academician V. Vakhidov during 2022–2024.
The patients were divided into four groups according to age and reproductive status: under 49 years, 50–58 years, 59–68 years, and 69 years and older.
General clinical, laboratory, instrumental, and statistical methods were used in the study. The patients' clinical conditions, coronary angiography findings, echocardiographic parameters, metabolic risk factors, respiratory function, and outcomes following myocardial revascularization were examined.
The study identified age- and reproductive-status-related clinical characteristics of ischemic heart disease in women. Relationships between disease severity, the extent of coronary artery involvement, and quality of life were assessed.
The study established an association between type 2 diabetes mellitus and a more severe course of ischemic heart disease in women, reduced left ventricular function, and a higher frequency of multivessel coronary artery involvement.
The importance of comprehensive assessment of respiratory function and the oxygen delivery index was also determined. Algorithms were developed for selecting endovascular coronary stenting and coronary artery bypass grafting based on clinical and demographic, anatomical and functional parameters, SYNTAX score, EuroSCORE II, diabetic status, and metabolic syndrome.
The number of registered cases of ischemic heart disease among women in the Republic of Uzbekistan increased from 133,325 in 2022 to 181,998 in 2024, representing a 36.5% increase.
The study found that increasing age was associated with a higher frequency of multivessel coronary artery involvement, comorbid conditions, and changes in cardiac function. The SYNTAX score increased from 7.5 points in women under 49 years of age to 29.2 points in women over 69. At the same time, quality-of-life indicators decreased with increasing age.
The outcomes of two major myocardial revascularization methods — endovascular coronary stenting and coronary artery bypass grafting — were comparatively analyzed. Following endovascular coronary stenting, left ventricular ejection fraction increased from 51.1% to 60.0%. Following coronary artery bypass grafting, this parameter increased from 51.7% to 66.2%.
According to the study findings, complete myocardial revascularization was achieved in 89.6% of cases following endovascular coronary stenting and in 90.5% of cases following coronary artery bypass grafting.
The analysis of treatment outcomes demonstrated the importance of selecting the revascularization method according to the patient's age, the extent of coronary artery involvement, SYNTAX score, EuroSCORE II, and comorbid conditions.
The research findings make it possible to individualize diagnostic and surgical treatment strategies for women with ischemic heart disease.
The developed algorithms enable the selection of an optimal myocardial revascularization method by taking into account the patient's age, extent of coronary artery involvement, cardiac function, diabetes mellitus, and chronic kidney failure.
Implementation of the research findings in clinical practice is aimed at improving treatment effectiveness, achieving complete revascularization, reducing the risk of complications, and improving long-term clinical outcomes.
The research findings confirm that age, reproductive status, metabolic disorders, and the extent of coronary artery involvement have a significant impact on the clinical course of ischemic heart disease and treatment outcomes in women.
Selecting the myocardial revascularization method based on individual risk indicators, refining the indications for endovascular coronary stenting and coronary artery bypass grafting, and implementing the developed algorithms in clinical practice contribute to improving the quality of patient care.
On November 24, 2026, at 14:00, the next meeting of the One-Time Scientific Council under Scientific Council DSc.06/2025.27.12.Tib.08.01 at the Republican Specialized Scientific and Practical Medical Center of Surgery named after Academician V. Vakhidov will take place.
Defense of the dissertation submitted by Mokhima Abdullaevna Abdullaeva on the topic: “Conceptual Aspects of Diagnosis and Surgical Treatment Strategies for Women with Ischemic Heart Disease”, submitted for the degree of Doctor of Medical Sciences (DSc) in the specialties 14.00.34 — “Cardiovascular Surgery” and 14.00.33 — “Public Health. Healthcare Management”.
Scientific Advisors: Doctor of Medical Sciences, Professor
Saydimurad Ibragimovich Ismailov,
Doctor of Medical Sciences, Professor
Mirjamol Mirumarovich Zufarov.
Official Opponents:
Leading Organization: Federal State Budgetary Institution “A.V. Vishnevsky National Medical Research Center of Surgery” (Russia).
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Download the dissertation abstract on “Conceptual Aspects of Diagnosis and Surgical Treatment Strategies for Women with Ischemic Heart Disease”.